METHOD OF PROVIDING A PATTERN OF BIOLOGICAL-BINDING AREAS FOR BIOLOGICAL TESTING
摘要
The present invention provides a method of forming one or more biological-binding areas on a substrate for biological-testing. The method includes activating at least a portion of a glass- ceramic substrate comprising glass and one or more metal containing compounds. The one or more metal containing compounds have a range of diameters that are less than about 300 nanometers in diameter and are spaced an average distance of at least one-half the midpoint of the diameter range apart. The one or more metals include compounds selected from metal oxides, metal nanoparticles, metal alloys, and atomic metals. The glass-ceramic substrate is heated to a temperature near the glass transformation temperature to form one or more metal nanoparticles in one or more ceramic biological-binding areas. The glass-ceramic substrate is etched to expose one or more metal. One or more biological molecules are contacted with one or more ceramic biological-binding areas to provide one or more biological testing areas with an increased binding area as compared to un-activated areas.
申请公布号
WO2009029733(A3)
申请公布日期
2009.04.23
申请号
WO2008US74699
申请日期
2008.08.28
申请人
LIFE BIOSCIENCES, INC.;FLEMMING, JEB, H.;BUCKLEY, COLIN, T.;SCHMIDT, CARRIE, F.
发明人
FLEMMING, JEB, H.;BUCKLEY, COLIN, T.;SCHMIDT, CARRIE, F.