发明名称 |
COMPOSITIONS COMPRISING OPTIMIZED HER1 AND HER3 MULTIMERS AND METHODS OF USE THEREOF |
摘要 |
The invention provides for compositions comprising engineered Her3 multimers with improved binding affinity. Such multimers include, but are not limited to, Herl/Her 3 heterodimers in which the Her3 ligand binding domain has been optimized to increase binding to Her3. The composition also can include mixtures of Her 1 homodimers, Her 3 homodimers, and Her 1/Her 3 heterodimers. |
申请公布号 |
WO2009052184(A2) |
申请公布日期 |
2009.04.23 |
申请号 |
WO2008US79998 |
申请日期 |
2008.10.15 |
申请人 |
RECEPTOR BIOLOGIX, INC.;SHEPARD, H., MICHAEL;JIN, PEI |
发明人 |
SHEPARD, H., MICHAEL;JIN, PEI |
分类号 |
C07K14/71;A61K38/17 |
主分类号 |
C07K14/71 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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