SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS

摘要

Compounds, pharmaceutically acceptable salts, stereoisomers and prodrugs thereof, that are ER ligands and particularly to such compounds that are ER beta-selective and/or ER beta-specific ligands. Compounds herein include certain compounds which are ER beta-selective agonists. Compounds herein include ER beta- selective agonists which exhibit minimal agonist or antagonist effect on ER alpha. Compounds of the invention include those of Formula (I) and any pharmaceutically acceptable salts, stereoisomers and prodrugs thereof wherein AR, R1, R3, and X1-X4 are as defined hereinabove.