摘要 |
The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation, and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1 -phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted. In one embodiment, the immune-derived moiety is a humanized monoclonal antibody that is reactive against sphingosine-1 -phosphate. |
申请人 |
LPATH THERAPEUTICS, INC.;SABBADINI, ROGER, A.;GARLAND, WILLIAM, A.;STOLLER, GLENN, L. |
发明人 |
SABBADINI, ROGER, A.;GARLAND, WILLIAM, A.;STOLLER, GLENN, L. |