发明名称 |
(R)-4-(HETEROARYL) PHENYLETHYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
<p>The present invention relates to a novel class of (R)-4-(heteroaryl)phenylpropionic derivatives of formula (I), useful in the inhibition of the chemotactic activation induced by the fraction C5a of complement. Said compounds are useful in the treatment of pathologies depending on the chemotactic activation of neutrophils and monocytes induced by the fraction C5a of the complement. In particular, the compounds of the invention are useful in the treatment of autoimmune hemolytic anemia (AIHA), psoriasis, bullous pemphigoid, rheumatoid arthritis, ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of injury caused by ischemia and reperfusion.</p> |
申请公布号 |
WO2009050258(A1) |
申请公布日期 |
2009.04.23 |
申请号 |
WO2008EP64023 |
申请日期 |
2008.10.17 |
申请人 |
DOMPE S.P.A.;MORICONI, ALESSIO;ARAMINI, ANDREA |
发明人 |
MORICONI, ALESSIO;ARAMINI, ANDREA |
分类号 |
C07D413/12;A61K31/422;A61K31/427;A61P37/00;C07D417/12 |
主分类号 |
C07D413/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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