PROCESS FOR THE PREPARATION OF AN ENANTIOMERICALLY AND/OR DIASTEREOMERICALLY ENRICHED ESTER, THIOESTER, ALCOHOL OR THIOL
摘要
<p>The invention relates to a process for preparing an enantiomerically and/or diastereomerically enriched ester or thioester having at least two adjacent chiral centres, wherein a mixture of stereoisomers of a secondary alcohol or thiol having a structure comprising a first chiral center forming a secondary alcohol or secondary thiol moiety in the beta position relative to a second chiral center having one hydrogen substituent, is reacted with an acyl donor in the presence of an epimerisation catalyst and a stereoselective acylation catalyst.</p>
申请公布号
WO2009050216(A1)
申请公布日期
2009.04.23
申请号
WO2008EP63915
申请日期
2008.10.15
申请人
DSM IP ASSETS BV;VERZIJL, GERARDUS, KAREL, MARIA;QUAEDFLIEG, PETER, JAN, LEONARD, MARIO;BROXTERMAN, QUIRINUS BERNARDUS
发明人
VERZIJL, GERARDUS, KAREL, MARIA;QUAEDFLIEG, PETER, JAN, LEONARD, MARIO;BROXTERMAN, QUIRINUS BERNARDUS