NOVEL MOLECULES AND MECHANISM FOR THERAPY

摘要

Identified is a sequence in Gli3 partly conserved in Gli2 and not found in Gli1, which contains the Gli repressor domain. This domain, parts of it or variants of it is expressed to achieve gene transcription repression. This will be of particular value for treatment of cancer and other pathologies arising from aberrant Hedgehog signaling or aberrant activation of gene transcription by Gli proteins.