MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 (MAP3K14) POLYMORPHISMS AS INDICATORS OF SUBJECT OUTCOME IN CRITICALLY 111 SUBJECTS
摘要
<p>The present application provides methods, uses, commercial packages, and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition and for identifying subjects having a greater benefit from treatment with an anti-inflammatory agent or an anti-coagulant agent. The method generally includes determining the genotype at position rs7222094 or a polymorphic site in linkage disequilibrium thereto for a subject for a polymorphisms in the these genes. The application also provides for methods of identifying potential subjects having an inflammatory condition who are more likely to benefit from treatment with an anti-inflammatory agent or anti-coagulant agent and to recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.</p>
申请公布号
WO2009033282(A1)
申请公布日期
2009.03.19
申请号
WO2008CA01612
申请日期
2008.09.10
申请人
THE UNIVERSITY OF BRITISH COLUMBIA;SIRIUS GENOMICS INC.;WALLEY, KEITH, R.;RUSSEL, JAMES, A.;MOODER, KAREN, PATRICIA