发明名称 |
MEDICINAL AGENT FOR DISEASE ASSOCIATED WITH EPSTEIN-BARR VIRUS, AND METHOD FOR SCREENING OF THE MEDICINAL AGENT |
摘要 |
1-(2-Fluoro-4-thio-ß-D-arabinofuranosyl)-5-methyluracil exhibits an anti-EB virus activity, and is therefore effective as a prophylactic or therapeutic agent for a disease associated with an EB virus. Each of a plasmid capable of expressing EB virus-TK and a plasmid capable of expressing human-TK is introduced into a TK-defect cell, thereby producing two types of cells respectively having the plasmids introduced therein. By using the two types of cells, it is possible to screen a medicinal agent which has cytotoxicity against the cell having the plasmid capable of expressing EB virus-TK introduced therein but has no toxicity against the cell having the plasmid capable of expressing human-TK introduced therein. In this manner, it becomes possible to screen a medicinal agent which specifically exhibits an anti-EB virus activity.
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申请公布号 |
CA2698645(A1) |
申请公布日期 |
2009.03.19 |
申请号 |
CA20082698645 |
申请日期 |
2008.09.08 |
申请人 |
KYOTO UNIVERSITY;YAMASA CORPORATION |
发明人 |
KODAMA, EIICHI;MATSUOKA, MASAO;ASHIDA, NORIYUKI |
分类号 |
A61K31/7072;A61P31/12;A61P35/00;C12Q1/02 |
主分类号 |
A61K31/7072 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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