发明名称 ELIMINATION OF HETEROGENEOUS OR MIXED CELL POPULATION IN TUMORS
摘要 Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
申请公布号 US2009076263(A1) 申请公布日期 2009.03.19
申请号 US20080186411 申请日期 2008.08.05
申请人 IMMUNOGEN INC. 发明人 GOLDMAKHER VIKTOR S.;LUTZ ROBERT J.;CHARI RAVI V.J.;KOVTUN YELENA V.;LAMBERT JOHN M.;STEEVES RITA;ERICKSON HANS K.
分类号 C07D498/12 主分类号 C07D498/12
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