METHODS AND COMPOSITIONS FOR INHIBITING VASCULAR LEAKAGE

摘要

Described are fumagillol derivatives and compositions and formulations thereof, and more particularly compositions and formulations of fumagillol derivatives wherein the fumagillol derivative is associated with a diblock copolymer. The present invention also relates to compositions and formulations comprising fumagillol derivatives for oral administration or administration via routes such as topical or ocular administration. The present invention also provides methods to treat angiogenesis-mediated conditions by administering the compositions and formulations comprising fumagillol derivatives as disclosed herein.