发明名称 |
Altered insulin-like growth factor binding proteins |
摘要 |
Altered IGFBPs are able to bind IGF, but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and to two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by use of the altered IGFBPs.
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申请公布号 |
US2009075876(A1) |
申请公布日期 |
2009.03.19 |
申请号 |
US20080073134 |
申请日期 |
2008.02.29 |
申请人 |
THE UNIVERSITY OF ADELAIDE |
发明人 |
FORBES BRIONY |
分类号 |
C07K14/435;A61K38/00;A61K38/17;A61P35/00;A61P35/04;C07H21/04;C07K14/47;C12N1/00;C12N5/10;C12N15/12 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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