METHODS OF INHIBITING TUMOR CELL PROLIFERATION WITH FOXM1 siRNA

摘要

The invention provides methods for inhibiting tumor cell proliferation by inhibiting Fox M1B (also called Fox M1) activity in a tumor cell. The invention also provides FoxM1B siRNA molecules and pharmaceutical compositions comprising FoxM1B siRNA molecules, wherein the siRNA molecules can inhibit FoxM1B activity and can inhibit proliferation of tumor cells. The invention further provides methods for preventing tumor growth, progression or both in an animal comprising inhibiting FoxM1B activity using siRNA molecules or pharmaceutical compositions comprising FoxM1B siRNA molecules.