PEPTIDE

摘要

The invention encompasses a novel peptide with antimicrobial activity, particularly but not only against Gram-negative bacteria, and uses thereof. The peptide is non-cyclic and comprises or consists of an antimicrobial domain that adopts an alpha-helix conformation upon interaction with a negatively- charged membrane. The antimicrobial domain has a sequence shown by formula (IV) : X1- X2 -X3 - X4- X5 - X6- X7 - X8-X9 X10-X11-X12-X13-X14-X15-X16 (SEQ ID NO: 7), in which X1, X5, X10 and X13 are each independently K or R; X15 is C; and the remaining residues are as specified herein. An examplar peptide is RPAFRKAAFRVMRACV ("RTA3"; SEQ ID NO: 9).