Zwitterionic connections and their use

摘要

Amide compounds (I) are new. Amide compounds of formula X[-C(=O)-NH-(CH 2) n-N +>(R 1>)(R 2>)-Y 1>-C(=O)-O ->] m(I), are new. R 1>, R 2>1-6C-aliphatic hydrocarbyl; Y 1>divalent hydrocarbyl; X : m-bonded residue or covalent bond; m : 1-4; and n : 1-6, provided that: (1) when m is 1, then X is H, ethyl, hydroxymethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1-hydroxypropyl, 2-hydroxypropyl or 3-hydroxypropyl; (2) when m is 2, then X is a direct covalent bond or divalent 1-5C hydrocarbyl optionally substituted by at least one OH, and (3) when m is greater than 2, then X is m-bonded 1-5C hydrocarbyl optionally substituted by at least 1 OH. An independent claim is included for the preparation of (I). ACTIVITY : Dermatological; Antiinflammatory; Antipsoriatic; Antiulcer; Immunosuppressive; Antiallergic; Endocrine-Gen. MECHANISM OF ACTION : None given.