| 摘要 |
a safe bio-degradable/absorbable polymer having an extremely low metal catalyst content while retaining properties desired for a medical implant; a process for the production of the polymer; and a method for reducing the content of a metal catalyst in a bio-degradable/absorbable polymer, which can be applied on an industrial scale. Specifically, disclosed is a process for the production of a bio-degradable/absorbable polymer having a content of a metal catalyst of less than 1 ppm in terms of a metal, comprising the following steps (1) and (2): (1) copolymerizing lactide and I-caprolactone at a molar ratio ranging from 40/60 to 60/40 in the presence of a metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a ratio ranging from 25/75 to 45/55 by volume at a temperature lower than 40°C, and then drying the copolymer. Also specifically disclosed is a process for the production of a bio-degradable/absorbable polymer having a content of a metal catalyst of less than 1 ppm in terms of a metal, comprising the following steps (1) and (2): (1) copolymerizing lactide and I-caprolactone at a molar ratio ranging from 65/35 to 85/15 in the presence of a metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a ratio ranging from 45/55 to 55/45 by volume at a temperature lower than 40°C, and then drying the copolymer.
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