发明名称 |
HIV ENV PROTEINS WITH MODIFICATIONS IN THE V3 LOOP |
摘要 |
<p>The invention concerns modification of the V3 loop of the HIV envelope glycoprotein in order to alter its Tat-binding properties. The invention provides a mixture of (i) a HIV Tat polypeptide and (ii) a HIV Env polypeptide, wherein the Env polypeptide has one or more mutations in its V3 loop. Also a method comprising a step of: combining a HIV Env polypeptide with a HIV Tat polypeptide, wherein the Env polypeptide has one or more mutations in its V3 loop. Also a mixture of (i) a HIV Tat polypeptide and (ii) a polypeptide comprising a fragment of a V3 loop of a HIV Env polypeptide.</p> |
申请公布号 |
CA2697370(A1) |
申请公布日期 |
2009.03.05 |
申请号 |
CA20082697370 |
申请日期 |
2008.08.25 |
申请人 |
NOVARTIS AG |
发明人 |
BARNETT, SUSAN W.;LIAN, YING;SHARMA, VICTORIA;SRIVASTAVA, INDRESH K. |
分类号 |
A61K39/21;C07K14/16 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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