发明名称 |
ENCODED SELF-ASSEMBLING CHEMICAL LIBRARIES (ESACHEL) |
摘要 |
<p>The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or functional analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1′) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a second embodiment according to the invention, the chemical compound which comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) is characterized in that the chemical compound further comprises at least one self-assembly moiety (m) capable of performing a combination reaction with at least one self-assembly moiety (m′) of a similar chemical compound comprising a chemical moiety (q). The invention comprises corresponding libraries of chemical compounds as well as methods of biopanning of target molecules and of identifying such targets.</p> |
申请公布号 |
EP1483585(B1) |
申请公布日期 |
2009.03.04 |
申请号 |
EP20020735257 |
申请日期 |
2002.04.15 |
申请人 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH |
发明人 |
NERI, DARIO;MELKKO, SAMU |
分类号 |
G01N33/58;C07H21/00;C12Q1/68;C40B30/04;C40B40/06 |
主分类号 |
G01N33/58 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|