METHOD FOR PREPARING OPTICALLY ACTIVE ALKYL 3-HYDROXYBUTANOATE DERIVATIVES

摘要

Provided is a method for preparing an optically active alkyl 3-hydroxy butanoate derivative from a racemic beta-lactone derivative by using a specific lipase biocatalyst. A method for preparing an alkyl 3- hydroxy butanoate derivative with high optical activity comprises the following steps of reacting a beta-lactone derivative represented by the formula 1 to ROH to obtain a compound, represented by the formula 1, as a (S)-type optical activator and a compound, represented by the formula 3, as a (R)-type optical activator in the presence of a Candida Antarctica-derived lipase, Pseudomonas cepacia-derived lipase, Rhizomucor miehei-derived lipase, Burkholderia cepacia-derived amino PS lipase, amino lipase PS-CI, amino lipase PS-CII, amino lipase PS-DI, or a lipase-OF catalyst.