| 摘要 |
PROBLEM TO BE SOLVED: To provide a surface acoustic wave device biosensor capable of detecting a process of propagation-growth-injury repairing of a cell, which is observed conventionally only by an optical microscope, by measuring it as a surface acoustic wave (SAW) propagation characteristic due to physical and chemical changes of the cell formed on an SAW propagation route, using an SAW generated on a piezoelectric substrate. SOLUTION: A high-frequency current or voltage is applied/impressed to an IDT 23 joined to the piezoelectric substrate 22, the SAW 25 is generated in the vicinity of a surface of the piezoelectric substrate 22, and the physical and chemical changes of the cell of the SAW are detected based on the propagation characteristic of the SAW 25, in this SAW device biosensor 21 of the present invention. In this SAW device biosensor 21, SiO<SB>2</SB>is film-formed onto the IDT 23, a pseudo-matrix 27 is coating-treated thereafter on the piezoelectric substrate 22, the SAW propagation route 24 comprising a culture cell 28 is formed to be constituted into dual channels, a change caused by a temperature and a solution mass is corrected in one of the channels, and the physical and chemical changes of the cell are detected in the other one channel. COPYRIGHT: (C)2009,JPO&INPIT
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