| 摘要 |
The present invention relates to the new use of alpha-ketoglutarate, amid es, and salts and mixtures thereof for the manufacture of a pharmaceutical p reparation or a food or feed supplement for the in vivo therapeutic improvem ent of blood vessel elasticity, in particular arterial elasticity in a subje ct in need thereof. Improving the blood vessel elasticity may be used in the for the treatment and/or prophylaxis of hypertension, pulmonary arterial hy pertension, cardiovascular disease, retinal vascular disease, heart failure, atherosclerosis, ventricular hypertrophy, stroke, arterial aneurysm, kidney failure, nephrosclerosis and diseases related to hypertension. |
