摘要 |
<p>Processes are provided for preparing bisphosphonic acids, wherein phosphorous acid and phosphorous halide compound are fed into composition comprising imidazole-1 - ylacetic acid, or the like, and polar solvent; the reaction mixture remains stirrable and is quenched by inputting into water; and after cooling, bisphosphonic acid can be isolated, wherein R1 comprises: i) CH3 , Formulae ii), iii), iv), v), vi), vii), viii) and ix).</p> |
申请人 |
ALBEMARLE CORPORATION;LIU, YUNQI;DELAUP, AARON, J. |
发明人 |
LIU, YUNQI;DELAUP, AARON, J. |