<p>A composition comprising a RSK activity inhibiting agent is provided for use in inhibiting angiogenesis. Inhibition of RSK activity has been found by applicant to inhibit endothelial migration, an important first step in the process of angiogenesis. The RSK specific inhibitors used in accordance with the disclosed composition and methods can be selected from any inhibiting moiety including but not limited to anti-sense oligonucleotides, interfering oligonucleotide and kaempferol 3-O-(3",4"-di-O-acetyl-a-L-rhamnopyranoside) and related compounds.</p>
申请公布号
WO2008157230(A1)
申请公布日期
2008.12.24
申请号
WO2008US66708
申请日期
2008.06.12
申请人
UNIVERSITY OF VIRGINIA PATENT FOUNDATION;LUNA INNOVATIONS INCORPORATED;LANNIGAN-MACARA, DEOBRAH, A.;SMITH, JEFFREY, A.;ANDRADE, JOSEFA;MAYHEW, MARK, W.
发明人
LANNIGAN-MACARA, DEOBRAH, A.;SMITH, JEFFREY, A.;ANDRADE, JOSEFA;MAYHEW, MARK, W.