发明名称 |
INTERFERON-ß PRODUCTION MODULATING LISTERIA STRAINS AND METHODS FOR USING SAME |
摘要 |
Mutant Listeria bacteria that modulate interferon-ß production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR gene, a MarR gene a MdrL gene, a MdrT gene and a MdrM gene. The subject bacteria find use in a variety of applications, where representative applications of interest include, but are not limited to: (a) use of the subject bacteria as adjuvants; (b) use of the subject bacteria as delivery vectors for introducing macromolecules into a cell; (c) use of the subject bacteria as vaccines for eliciting or boosting a cellular immune response; etc. |
申请公布号 |
WO2008066774(A3) |
申请公布日期 |
2008.12.24 |
申请号 |
WO2007US24359 |
申请日期 |
2007.11.21 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;PORTNOY, DANIEL A.;HERSKOVITS, ANAT A.;CRIMMINS, GREGORY |
发明人 |
PORTNOY, DANIEL A.;HERSKOVITS, ANAT A.;CRIMMINS, GREGORY |
分类号 |
C12N1/21;A61K39/02;C12N1/36 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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