发明名称 |
ASSAYS TO PREDICT ATHEROSCLEROSIS AND DYSFUNCTIONAL HIGH-DENSITY LIPOPROTEIN |
摘要 |
This invention provides novel assays for the detection of dysfunctional HDL. The assays are good diagnostics and/or prognostics for atherosclerosis or other pathologies characterized by an inflammatory response. In certain embodiments the methods involve measurements of heme-related HDL-associated proteins (e.g., haptoglobin, hemopexin, etc.), and/or measurements of the relative distribution of HDL-associated proteins between HDL and the non-lipoprotein fractions of plasma/serum, and/or measurements of the ability of pro-inflammatory HDL to consume nitric oxide, and/or measurement of the ability of HDL to inhibit LDL aggregation. |
申请公布号 |
WO2007095126(A3) |
申请公布日期 |
2008.12.24 |
申请号 |
WO2007US03588 |
申请日期 |
2007.02.09 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;FOGELMAN, ALAN, M.;REDDY, SRINIVASA, T. |
发明人 |
FOGELMAN, ALAN, M.;REDDY, SRINIVASA, T. |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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地址 |
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