PHARMACEUTICAL SOLID PREPARATION COMPRISING BENZAZEPINES ANDPRODUCTION METHOD THEREOF

摘要

The subject invention provides a novel pharmaceutical solid preparation t hat has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointesti nal tract. The pharmaceutical solid preparation of the present invention com prises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]- 2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcel lulose containing a hydroxypropoxyl group in an amount of 50 wt.% or greater ; and (c) at least one member selected from the group consisting of carmello se, sodium carboxy methyl starch, crospovidone, and low substituted hydroxyp ropylcellulose with an average particle diameter of 30 to 70µm, and a 90% cu mulative particle diameter of 100 to 200µm.