发明名称 ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11 BETA -HYDROXYSTEROID DEHYDROGENASE TYPE I
摘要 Disclosed is a compound useful as an inhibitor of 11²-hydroxysteroid dehydrogenase type 1. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is a group of the formula: -C(=O)NR 4 R 5 , (wherein R 4 and R 5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: -NR 6 C(=O)R 7 , (wherein R 6 and R 7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently -0- or the like, Z is a bond or the like, R 2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R 3 is optionally substituted alkyl, optionally substituted alkenyl or the like.
申请公布号 EP2006286(A2) 申请公布日期 2008.12.24
申请号 EP20070739976 申请日期 2007.03.28
申请人 SHIONOGI CO., LTD. 发明人 OGAWA, TOMOYUKI;CHOMEI, NOBUO;MASUDA, KOJI;TANAKA, SATORU
分类号 C07D261/18;A61K31/42;A61K31/425;A61K31/454;A61P3/10;A61P43/00;C07D275/02;C07D413/12 主分类号 C07D261/18
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