| 摘要 |
PROBLEM TO BE SOLVED: To provide a vaccine containing at least one antigen and an immunostimulatory substance. SOLUTION: The invention relates to a vaccine which comprises at least one antigen and a peptide comprising a sequence R<SB>1</SB>-XZXZNXZX-R<SB>2</SB>(wherein N may be any number between 3 and 7, and preferably 5; X is a positively charged natural and/or non-natural amino acid residue; Z is an amino acid residue selected from the group consisting of L, V, I, F and/or W, and R<SB>1</SB>and/or R<SB>2</SB>are selected independently from one another from the group consisting of -H, -NH<SB>2</SB>, -COCH<SB>3</SB>, -COH, a peptide with up to 20 amino acid residues or a peptide reactive group or a peptide linker with or without a peptide; X-R<SB>2</SB>may also be an amide, ester or thioester of the C-terminal amino acid residue), as well as relates to the use of the peptide for the preparation of an adjuvant for enhancing the immune response to at least one antigen. COPYRIGHT: (C)2008,JPO&INPIT |
