MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE

摘要

The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R¹, R², R³, R⁵, R⁶, R⁸, M¹, M², M³, M⁴, M⁵, M⁶ and M⁷ are each independently a member selected from the group consisting of H, C_1-6 alkyl, OH and C_1-6 hydroxyalkyl; R⁴, R⁷ and R⁹ are each independently selected from the group consisting of C_1-6 alkoxy and OH; R¹⁰ is a member selected from the group consisting of H, -OH, -OP(O)Me₂, -O-(CH₂)_n-OH and -O-(CH₂)_m-O-(CH₂)_o-CH₃, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L¹ and L⁴ are independently selected from the group consisting of: wherein each M⁸ is independently a member selected from the group consisting of C_1-6 alkyl, OH and C_1-6 hydroxyalkyl; each of L² and L³ are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.