发明名称 |
RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF PCSK9 |
摘要 |
The present invention provides compounds, compositions and methods for modulating the expression of PCSK9. In particular, this invention relates to oligomeric compounds, such as oligonucleotide compounds, which are hybridisable with target nucleic acids encoding PCSK9, and methods for the preparation of such oligomeric compounds. The oligonucleotide compounds have been shown to modulate the expression of PCSK9, and pharmaceutical preparations thereof and their use as treatment of hypercholesterolemia and related disorders are disclosed. |
申请公布号 |
WO2008043753(A3) |
申请公布日期 |
2008.09.25 |
申请号 |
WO2007EP60703 |
申请日期 |
2007.10.09 |
申请人 |
SANTARIS PHARMA A/S;STRAARUP, ELLEN MARIE;NIELSEN, NIELS FISKER |
发明人 |
STRAARUP, ELLEN MARIE;NIELSEN, NIELS FISKER |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|