PSYCHOTROPIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE

摘要

The present invention provides a method for treating or preventing a disease or disorder treatable by the inhibition of serotonin reuptake in a patient, and/or norepinephrine reuptake and/or dopamine reuptake in a patient, the method comprising administering to the patient a neurotransmitter reuptake inhibiting-effective amount of at least one compound of the formula A-L-B (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein A is a psychotropic derivative; L is a linking group comprising two carbon atoms; and B is an alkyl, alkenyl, alkynyl or aralkyl comprising at least one substituent of the formula Q, wherein: the alkyl, alkenyl, alkynyl or aralkyl is optionally substituted with one or more halogens, hydroxyl, cyano, nitro, amino or thiol; and Q is OR<SUP>6</SUP>, OC(O)R<SUP>6</SUP>, C(O)R<SUP>6</SUP>, C(S)R<SUP>6</SUP>, CO2R<SUP>6</SUP>, C(O)SR<SUP>6</SUP>, C(O)NR<SUP>6</SUP>R<SUB>7</SUB>, C(S)NR<SUP>6</SUP>R<SUP>7</SUP>, NR<SUP>6</SUP>R<SUB>7</SUB>, NR<SUB>6</SUB>C(O)R<SUB>7</SUB>, NR<SUP>6</SUP>C(S)R<SUP>7</SUP>, NR<SUP>6</SUP>C(O)NR<SUP>7</SUP>R<SUP>8</SUP>, NR6C(S)NR<SUP>7</SUP>R<SUP>8</SUP>, NR<SUP>6</SUP>SO2R<SUP>7</SUP>, NR<SUP>6</SUP>SO2NR<SUP>7</SUP>R<SUP>8</SUP>, SR<SUP>6</SUP>, SC(O)R<SUP>6</SUP>, SC(O)NR<SUP>6</SUP>R<SUP>7</SUP>, S(O)R<SUP>6</SUP>, SO2R<SUP>6</SUP>, SO2NR<SUP>6</SUP>R<SUP>7</SUP>, or NR<SUP>6</SUP>SO2NR<SUP>7</SUP>R<SUP>8</SUP>.