HEPATIC MARKER PROTEINS FOR INSULIN RESISTANCE

摘要

The present disclosure relates to marker proteins expressed in abnormally low or high concentration in liver tissue of individuals suffering from diabetes or early stages thereof. Such hepatic markers are effective in diagnosing diabetes or pre-diabetes. The disclosure further provides methods for identifying an agent for treating a diabetic or pre-diabetic individual. In some embodiments, the methods comprise the steps of: (i) contacting an agent to a mixture comprising at least one polypeptide selected from Table 1 ; and (ii) selecting an agent that modulates the expression or activity of at least the one polypeptide or that binds to the polypeptide, thereby identifying an agent for treating a diabetic or pre-diabetic individual. In some embodiments, the methods further comprise selecting an agent that modulates insulin sensitivity.