<p>The present invention provides novel macrocyclic compounds that mimic peptide substrates of the hepatitis C viral protease and inhibit the viral protease, more particularly as inhibitors of the NS3 serine protease from hepatitis C virus. Methods for synthesis of the compounds are also provided. The compounds find utility as antiviral agents directed at hepatitis C. The invention further provides methods of employing such inhibitors, alone or in combination with other therapeutic agents, to treat hepatitis C infection in a subject in need of such treatment.</p>
申请公布号
WO2008086161(A1)
申请公布日期
2008.07.17
申请号
WO2008US50208
申请日期
2008.01.04
申请人
PHENOMIX CORPORATION;CAMPBELL, DAVID ALAN;HEPPERLE, MICHAEL E.;WINN, DAVID T.;BETANCORT, JUAN MANUEL
发明人
CAMPBELL, DAVID ALAN;HEPPERLE, MICHAEL E.;WINN, DAVID T.;BETANCORT, JUAN MANUEL