PHARMAZEUTISCHE ZUBEREITUNGEN VON ANTINEOPLASTISCHEN WIRKSTOFFEN, INSBESONDERE TEMOZOLOMID, VERFAHREN ZU IHRER HERSTELLUNG UND DEREN VERWENDUNG

摘要

In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine or mixtures thereof; a lyophilized powder comprising said pharmaceutical formulation, and articles of manufacture thereof.