| 摘要 |
Peptides having four to fourteen residues are disclosed that possess biol ogical activity. These peptides constitute short fragments of the peptide HB -107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory pr operties. As keratinocytes are especially sensitive to these effects, the di sclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various envir onmental insults. Importantly, the therapeutic effects of the peptides manif est at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effecti ve therapies. Methods for the production and use of these peptides are also disclosed.
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