发明名称 |
SIVMAC239 IMMUNOGENIC PLASMIDS, RECOMBINANT ADENOVIRAL VECTORS, AND IMMUNIZATION PROTOCOL USING THE SAME THAT REDUCE VIRAL LOADS AFTER MUCOSAL SIVMAC239 INFECTION |
摘要 |
A DNA vaccine composition and a recombinant adenovirus vaccine composition using an SIVmac239/rhesus macaque model are provided to show excellent AIDS virus infection prophylactic and therapeutic effect when being applied to a priming-boosting technique, thereby being used as a novel agent for preventing and treating the AIDS. A priming vaccine composition for preventing or treating AIDS comprises: (a) an immunogenic plasmid including an SIV Gag gene and an Env gene; and (b) an immunogenic plasmid including a gene codon-optimized by nef-tat-vpx-vif-tat. A boosting vaccine composition for preventing or treating AIDS comprises: (a) a recombinant adenovirus including an SIV Gag gene and an Env gene; and (b) a recombinant adenovirus including an sVif-Nef gene and an sTat-Vpx gene. A vaccine kit for preventing or treating AIDS comprises the priming vaccine composition and the boosting vaccine composition. Further, the priming vaccine composition for preventing or treating AIDS additionally comprises a PLGA(poly lactic-co-glycolic acid)-Y peptide.
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申请公布号 |
KR20080066498(A) |
申请公布日期 |
2008.07.16 |
申请号 |
KR20070004002 |
申请日期 |
2007.01.12 |
申请人 |
POSTECH ACADEMY-INDUSTRY FOUNDATION;POSCO |
发明人 |
SUNG, YOUNG CHUL;PARK, KI SEOK;SUH, YOU SUK;KIM, KWANG SUN;AHN, SO SHIN |
分类号 |
C12N15/34;C12N15/09;C12N15/861 |
主分类号 |
C12N15/34 |
代理机构 |
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地址 |
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