DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE ß2 ADRENERGIC RECEPTOR

摘要

The present invention provides a Compound of formula (I), wherein: R¹ is a group selected from -CH₂OH,-NH(CO)H; and R² is a hydrogen atom; or R¹ together with R² form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R¹ and the carbon atom is bound to the carbon atom in the phenyl ring holding R²;^{R3a and R3b are independently selected from the group consisting of hydrogen atoms and C_1-4 alkyl groups; X and Y are independently selected from the group consisting of direct bond and oxygen atom; n, m and q each independently has a value selected from 0, 1, 2 and 3; p has a value selected from 1, 2 and 3; R4 and R5 are independently selected from hydrogen atoms, halogen atoms, C_1-4 alkyl, C_1-4 alkoxy, -CONH₂, -NHCONH₂, -SR7, -SOR7, -SO₂R7, -SO₂NHR8 and the groups (a) and (b), wherein R7 is selected from C_1-4alkyl and C_3-8 cycloalkyl and R8 is selected from hydrogen atoms and C_1-4alkyl groups; R6 is selected from the group consisting of hydrogen atoms, halogen atoms, C_1-4 alkyl and C_1-4 alkoxy or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.}