Medicament that is intended for oral administration, comprising a cyclooxygenase-2 inhibitor, and preparation method thereof

摘要

Disclosed is a medicament that is intended for oral administration and that has an improved bio-availability, said medicament comprising an agglomerate based on inert solid particles that are based on at least one excipient, said agglomerate comprising a cyclooxygenase-2 inhibitor and at least one hydrophilic polymer, characterized in that said agglomerate comprises the product of spraying said particles with a solution or suspension of micronized grains of said inhibitor in said polymer (s) in order to agglomerate said particles, and in that said inhibitor is composed of at least one compound of formula (I) and a salt or solvate of this compound, wherein the variables are as defined in the specification. Preferred compounds of formula (I) include imidazoles such as cimicoxib. The process of preparing said medicament is also disclosed.