| 摘要 |
PURPOSE: A pharmaceutical composition containing PDK4(Pyruvate dehydrogenase kinase 4) for suppressing vascular calcification is provided to suppress PDK4 expression or PDK4 protein activation. CONSTITUTION: A pharmaceutical composition for suppressing vascular calcification contains PDK4 inhibitor. The PDK4 inhibitor is dichloroacetate. The PDK4 inhibitor is a pharmaceutical composition selected from (R)-trifluoro-2 hydroxy-2 methoxypropionic acid, (R),3,3,3-trifluoro-2-hyudroxy-2-methylpropionic, leelamine, Co-A, NAD, insulin, piruvate and ADP.
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