发明名称 TREATMENT OF PROLIFERATIVE DISEASES WITH EPOTHILONE DERIVATIVES AND RADIATION
摘要 FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, particularly to treatment of proliferative disease especially that one associated with a solid tumour. That is ensured by introduction of an effective amount of epothilone B of formula I wherein residual A represents O, R stands for hydrogen or methyl, and Z means O. The patient is exposed to ionising radiation additionally, simultaneously or consistently in any order. ^ EFFECT: choice of a specific epothilone derivative combined with radiation provides synergetic effect on suppression of tumour tissue. ^ 8 cl, 1 ex
申请公布号 RU2381799(C2) 申请公布日期 2010.02.20
申请号 RU20050131723 申请日期 2004.03.12
申请人 NOVARTIS AG 发明人 PRUSHI MARTIN
分类号 A61K31/427;A61K41/00;A61N5/10;A61P35/00 主分类号 A61K31/427
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