| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: described is a method for preparation of a new class compounds represented by 1,2,3,6-tetrahydropropyrrolo[1,2-d][1,4]diazocine derivatives with a general formula of I-VI , where: I R1=Me R2=Me R3=CHO X=CO2Me; II R1=Et R2=MeR3=CHO X=CO2Me; III R1=Et R2=Me R3=CF3CO a) X=CO2Me, b) X=COMe; IV R1=Bn R2=Me R3=CHO X=CO2Me; V R1=Me R2=Ph R3=CHO a) X=CO2Me, b) X=COMe; VI R1=Me R2=Ph R3=CF3CO a) X=CO2Me, b) X=COMe that may be of interest in the capacity of nootropic preparations. The proposed method is as follows: the relevant 1,2,3,4-tetrahydropropyrrolo[1,2-a][1,4]diazocine derivative becomes dissolved in acetonitrile and undergoes interaction with two moles of H-CëC-X compound in combination with boiling during at least 7 hours, the residue produced after the reaction termination the solvent removal becomes purified by way of aluminium oxide column chromatography. ^ EFFECT: method for preparation of a new class compounds. ^ 1 cl, 9 ex |
