| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of obtaining derivatives of N-acetyl-4-hydroxy-2-methyl-5-(5-methylfur-2-yl)-1H-benzo[g]indole with general formula I: Ia-d lla-d I, lla R=H; R1=H, I, llb R=Cl; R1=H, I, llc R=Br; R1=H, I, Ild R-OCH3; I R1=OCH3, characterised by that formation of a furyl-substituted benzo[g]indole basic structure results from opening and re-closing of the annelated furan ring in the corresponding 2-alkyl-4-N,N-diacetylamino-9-(5-methyl-2-furyl)naphthofurans lla-d while boiling them for 1 minute in a 30% hydrogen chloride solution in ethanol. ^ EFFECT: method reduces resin formation of the reaction mass, allows for obtaining desired products with high output and widens the range of derivatives, which can be used in obtaining anti-inflammatory compounds. ^ 1 cl, 3 tbl, 5 ex |
