Modified peptide and the use thereof, DNA, expression vector, host cell, pharmaceutical composition, and a method of preparing the pharmacologically active compound

摘要

The present invention relates to a modified peptide of the general formula (X1)a-F1-(X2)b, and multimers thereof, wherein F1 is an Fc domain; X1 and X2 are each independently selected from -(L1)c-P1, -(L1)c-P1-(L2)d-P2, -(L1)c-P1-(L2)d-P2-(L3)e-P3, and -(L1)c-P1-(L2)d-P2-(L3)e-P3-(L4)f-P4 wherein P1, P2, P3 and P4 are each independently randomised sequences of pharmacologically active peptides; L1, L2, L3 and L4 are linkers; and a, b, c, d, e and f are 0 or 1, provided that at least one of a and b is 1, and wherein "peptide" refers to molecules of 2 to 40 amino acids and wherein neither X1 nor X2 is a native protein. The invention further relates to use of that product, a DNA encoding thereof, an expression vector containing the DNA, and a host cell containing the vector. The invention further relates to pharmaceutical composition containing that product. The pharmacologically active compounds are prepared by a process comprising: a) selecting a peptide that modulates the activity of a protein of interest; and b) preparing a compound comprising at least one Fc domain covalently linked to at least one amino acid of the selected peptide.