发明名称 |
METHOD FOR PRODUCING PEPTIDE |
摘要 |
The present invention provides a method for producing a peptide, characterized in that it comprises converting an -SH group of a peptide comprising an amino acid residue having the -SH group to an -OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an -SH group in a peptide to react with a methylating agent to convert the -SH group to an -SMe group; (b) allowing the -SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an -OH group under more basic conditions than the conditions in the step (b). |
申请公布号 |
EP2184290(A1) |
申请公布日期 |
2010.05.12 |
申请号 |
EP20080791890 |
申请日期 |
2008.07.30 |
申请人 |
OTSUKA CHEMICAL CO., LTD. |
发明人 |
KAJIHARA, YASUHIRO;SAKAMOTO, IZUMI;NAMBU, YURI;FUKAE, KAZUHIRO;ASAI, HIROAKI |
分类号 |
C07K1/113;C07K5/10;C07K7/06;C07K9/00;C07K14/46;C08B37/00 |
主分类号 |
C07K1/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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