New components and new bioreactor system for the culture and mechanical stimulation of biological material

摘要

The bioreactor comprises a bioreactor chamber, a culture unit, unit for execution of mechanical stimuli on the biological material to be cultivated, and a control- and/or regulation unit. The unit for execution of mechanical stimuli comprises two drives regulatable- and/or controllable to each other. A first drive is a piezo drive (71) that allows generation of mechanical stimuli and a second drive is a linear drive (61) that allows a regulation of position of the biological material in the bioreactor chamber. The piezo drive allows generation of mechanical stimuli with frequency of >= 5 Hz. The bioreactor comprises a bioreactor chamber, a culture unit, unit for execution of mechanical stimuli on the biological material to be cultivated, and a control- and/or regulation unit. The unit for execution of mechanical stimuli comprises two drives regulatable- and/or controllable to each other. A first drive is a piezo drive (71) that allows generation of mechanical stimuli and a second drive is a linear drive (61) that allows a regulation of position of the biological material in the bioreactor chamber. The piezo drive allows generation of mechanical stimuli with a maximum frequency of >= 5 Hz. The control- and/or regulation units are arranged in such a way that actual powers influential on the biological material are determined and the position of the biological materials in the bioreactor chamber is regulatable dependent upon the values measured at the power knife. Independent claims are included for: (1) a seal for sealing of bioreactor chamber; and (2) a bioreactor chamber.