PRODUCTION OF ITACONIC ACID

摘要

The invention relates to the production of itaconic acid in micro-organisms by introducting into a suitable host cell a gene coding for the enzyme cis -aconitic acid decarboxylase, preferably derived from A. terreus. Further production of itaconic acid can be boosted by introduction of a gene coding for the enzyme aconitase and/or the enzyme 2-methylcitrate dehydratase. Further part of the invention are host cells, preferably from A. niger , provided with the above mentioned genes.