发明名称 Method for in vivo delivery of active compounds using reagent conjugate
摘要 This invention relates to novel reagent conjugates and a novel multi-step process for delivering active compounds to target analytes of interest in a patient for diagnostic and therapeutic purposes. According to the process, two novel reagents are bound to each other by linkage of the sequence-specific components they contain. The first reagent, which is comprised of a target recognition component and a first sequence-specific component, is introduced into the patient and allowed to achieve maximal localization on the target cells. The second reagent, which is comprised of an active compound component and a second sequence-specific component is then introduced into the patient, thereby forming a complex with the first reagent via the recognition and binding of the sequence-specific components of the two reagents to form the reagent conjugate of the invention. The active compound component is thereby efficiently and specifically delivered to the target analyte.
申请公布号 US7713528(B1) 申请公布日期 2010.05.11
申请号 US19950486062 申请日期 1995.06.07
申请人 ENZO THERAPEUTICS, INC. 发明人 RABBANI ELAZAR;STAVRIANOPOULOS JANNIS G.;GOLTZ SHERRY P.
分类号 A61K39/395;A61K31/70;A61K51/00;C07K16/00;C07K16/30 主分类号 A61K39/395
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