ENHANCED PREPARATION METHOD OF OPTICAL (R)-PHENOXYPROPIONIC ACID-N-METHYL-N-2-FLUOROPHENYLAMIDE COMPOUND

摘要

PURPOSE: A method for preparing an optically active (R)-phenoxypropionic acid-N-methyl-N-2-fluorophenylamide compound is provided to easily isolate and purify and to maintain optical activity. CONSTITUTION: A method for preparing optically active (R)-phenoxypropionic acid-N-methyl-N-2-fluorophenylamide compound comprises: a step of reacting a compound of chemical formula 4 with a compound of chemical formula 5 under the presence of inactive solvent to obtain a compound of chemical formula 3; a step of performing chlorination of the compound of chemical formula 3 with chlorination reagent to obtain a compound of chemical formula 6; and a step of reacting a compound of chemical formula 7 with the compound of chemical formula 6 under the presence of inactive solvent and base.