发明名称 |
Massive parallel method for decoding DNA and RNA |
摘要 |
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
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申请公布号 |
US7713698(B2) |
申请公布日期 |
2010.05.11 |
申请号 |
US20070894690 |
申请日期 |
2007.08.20 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
JU JINGYUE;LI ZENGMIN;EDWARDS JOHN ROBERT;ITAGAKI YASUHIRO |
分类号 |
C12Q1/68;G01N33/53;C07B61/00;C07G3/00;C07H19/04;C07H19/10;C07H19/20;C07H21/00;C07H21/02;C07H21/04;C12N15/09;C12P19/34;G01N37/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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