Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.
申请公布号
CA2780482(A1)
申请公布日期
2010.05.10
申请号
CA20092780482
申请日期
2009.11.17
申请人
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM;UNT HEALTH SCIENCE CENTER AT FORT WORTH
发明人
SOOD, ANIL K.;LACKO, ANDRAS G.;LOPEZ-BERESTEIN, GABRIEL;MANGALA, LINGEGOWDA S.;MCCONATHY, WALTER J.;PROKAI, LASZLO;NAIR, MAYA P.